AGReMA is an evidence- and consensus-based guideline that provides recommendations for reporting primary and secondary mediation analyses of randomised trials and observational studies. It is designed to assist authors, peer-reviewers and journal editors to ensure accurate, consistent and transparent reporting of studies that use mediation analyses. 

The AGReMA initiative followed the EQUATOR (Enhancing the QUAlity and Transparency Of health Research) network methodological framework, including a consensus meeting with methodologists, statisticians, clinical trialists, epidemiologists, psychologists, clinical researchers, clinicians, implementation scientists, evidence synthesis experts, representatives of the EQUATOR network, and journal editors.

There are two versions of AGReMA: 

AGReMA is for studies that report mediation analyses as the primary focus of an article.

AGReMA-SF is for studies that report secondary mediation analyses within a primary report of a randomised trial or observational study.

Partners

The development of AGReMA was funded by the Berkeley Initiative for Transparency in the Social Sciences, a program of the Center for Effective Global Action (CEGA), with support from the Laura and John Arnold Foundation